Effects of Lambda cyhalothrin on Reproductive Characteristics in Pregnant Rabbit doe (Oryctolagus cuniculus)
Introduction: Lambda-cyhalothrin (LCT) is a manufactured pyrethroid insecticide, and has now become an environmental issue due to its excessive use in agriculture, livestock production, leather industry and shampoos. The present study was undertaken to evaluate the effects of LCT on reproductive characteristics in pregnant rabbit does.
Methods: Fifteen nulliparous and sexually mature rabbit does, aged 8 months and weighing 2.80-3.00 kg were divided into three groups of five animals, comparable in terms of body weight (bw). After mating, group T0 received distilled water, while groups T1 and T2 were administered doses of 4.16 and 8.32 mg/bw of LCT respectively. At 28th day post-coïtum, animals were sacrificed for evaluation of reproductive parameters. Data were subjected to one-way analysis of variance to observe significance difference against control.
Results: Results showed comparable (P > 0.05) values for reproductive organs weight no matter the organ nor the group of treatment considered. A dose-dependent decrease in serum progesterone concentration was noted; nevertheless, the difference was not significant (P > 0.05) among groups. Likewise, an insignificant (P > 0.05) decrease was observed in the number of implantation sites, live fetus, placenta and litter size; with an increase in the number of death fetuses, pre-implantation resorptions, post-implantation resorptions and total resorptions in lambda-cyhalothrin treated groups when compared with the control. A decrement was registered in fetus weight, lengths of the head, crown-rump, tail and total body length in the 2 groups treated with the pesticide as compared to the control group; though only significant (P < 0.05) in fetus weight.
Conclusion: The present study indicates that administration of lambda cyhalothrin at high doses exerts potentially adverse effects on the reproduction of rabbit does.
We are grateful for material support provided by the Head of the Laboratory of Animal Physiology and Health of the Uni-versity of Dschang, Cameroon.
Experimental protocols used in this study were approved by the Ethical committee of the Department of Animal Science of the University of Dschang (ECDAS-UDs 23/02/2015/UDs/FASA/DSAES) and was in conformity with the in-ternationally accepted standard ethical guide lines for lab-oratory animal use and care as described in the European Community guidelines; EEC Directive86/609/EEC, of the 24thNovember1986.
CONFLICTS OF INTEREST
The authors declare no conflict of interest.
This research received no external funding.
Conceptualization, design, data analysis and interpretation was done by M.T.M.A., N.F., V.B.N., and K.J. Data acquisi-tion was done by M.T.M.A., V.B.N., C.M.M.M., T.H., D.M.N. and D.N.A.B.; Drafting of the article was done by M.T.M.A., V.B.N. and C.M.M.M.
The data sets used during the current study are available from the corresponding author upon reasonable request.
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