Immunomodulatory Effects of Cholera Toxin B Subunit and Peptide LKEKK
The review analyzed data on immunomodulatory action of cholera toxin B subunit (CT-B) and the synthetic peptide LKEKK that corresponds to residues 16-20 in thymosin-α1 and 131-135 in interferon-α2 on the functional, NO-synthase and guanylate cyclase activity of T and B lymphocytes, of macrophage-like cell line RAW 264.7. According to the data pre-sented, CT-B and the peptide bind to the cholera toxin receptor of the target cell with high affinity and trigger the following cascade of intracellular reactions: activation of inducible NO synthase → increase in NO production → increase in soluble guanylate cyclase activity → increase in the cyclic guanosine-3’,5’-monophosphate level.
There is no acknowledgment for the present study.
This research was funded by Fundamental Research Program of the Presidium of RAS “Molecular and Cell Biology” (Grant # 0101-2014-0086).
EVN performed the study.
CONFLICTS OF INTEREST
There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.