Immunomodulatory Effects of Cholera Toxin B Subunit and Peptide LKEKK

  • Elena Navolotskay, * Branch of Shemyakin and Ovchinnikov, Institute of Bioorganic Chemistry, Moscow, Russian Federation https://orcid.org/0000-0003-4711-2723

Abstract

The review analyzed data on immunomodulatory action of cholera toxin B subunit (CT-B) and the synthetic peptide LKEKK that corresponds to residues 16-20 in thymosin-α1 and 131-135 in interferon-α2 on the functional, NO-synthase and guanylate cyclase activity of T and B lymphocytes, of macrophage-like cell line RAW 264.7. According to the data pre-sented, CT-B and the peptide bind to the cholera toxin receptor of the target cell with high affinity and trigger the following cascade of intracellular reactions: activation of inducible NO synthase → increase in NO production → increase in soluble guanylate cyclase activity → increase in the cyclic guanosine-3’,5’-monophosphate level.

Author Biography

Elena Navolotskay, *, Branch of Shemyakin and Ovchinnikov, Institute of Bioorganic Chemistry, Moscow, Russian Federation

avolotskaya@bibch.ru

Published
2020-09-06
Section
Review Article