Immunomodulatory Effects of Cholera Toxin B Subunit and Peptide LKEKK

  • Elena Navolotskay, * Branch of Shemyakin and Ovchinnikov, Institute of Bioorganic Chemistry, Moscow, Russian Federation https://orcid.org/0000-0003-4711-2723
Keywords: Protein, Peptide, Receptor, Cholera toxin B subunit, Immunocompetent cell, NO-synthase, Soluble guanylate cyclase, Immune system, Signal transduction

Abstract

The review analyzed data on immunomodulatory action of cholera toxin B subunit (CT-B) and the synthetic peptide LKEKK that corresponds to residues 16-20 in thymosin-α1 and 131-135 in interferon-α2 on the functional, NO-synthase and guanylate cyclase activity of T and B lymphocytes, of macrophage-like cell line RAW 264.7. According to the data pre-sented, CT-B and the peptide bind to the cholera toxin receptor of the target cell with high affinity and trigger the following cascade of intracellular reactions: activation of inducible NO synthase → increase in NO production → increase in soluble guanylate cyclase activity → increase in the cyclic guanosine-3’,5’-monophosphate level.

 

ACKNOWLEDGMENTS
There is no acknowledgment for the present study.
FUNDING
This research was funded by Fundamental Research Program of the Presidium of RAS “Molecular and Cell Biology” (Grant # 0101-2014-0086).
AUTHORS’ CONTRIBUTIONS
EVN performed the study.
ETHICAL STATEMENT
Not applicable.
CONFLICTS OF INTEREST
There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Author Biography

Elena Navolotskay, *, Branch of Shemyakin and Ovchinnikov, Institute of Bioorganic Chemistry, Moscow, Russian Federation

avolotskaya@bibch.ru

Published
2020-09-06
Section
Review Article